Vaccination is the best way to protect people and stop the transmission of Poliomyelitis. BODIAN D. A reconsideration of the pathogenesis of poliomyelitis. Download File PDF Pathogenesis Of Poliomyelitis Journal (PDF) Poliovirus, Pathogenesis of Poliomyelitis, and Apoptosis Journal of Infectious Diseases and Immunity Vol. 3(15), pp. Trends Microbiol 9:560–564, Umehara F, Nakamura A, Izumo S, Kubota R, Ijchi S, Kashio N, Hashimoto K-I, Usuku K, Sato E, Osame M (1994) Apoptosis of T lymphocytes in the spinal cord lesions in HTLV-I-associated myelopathy: a possible mechanism to control viral infection in the central nervous system. ASM Press, Washington DC, pp 71–83, Ida-Hosonuma M, Iwasaki T, Taya C, Sato Y, Li J, Nagata N, Yonekawa H, Koike S (2002) Comparison of neuropathogenicity of poliovirus in two transgenic mouse strains expressing human poliovirus receptor with different distribution patterns. 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[1] The virus, which mainly affects children under 5 years of age. 3(15), pp. These include the mechanisms determining the progression to viremia, the pathogenesis of neuronal infection and paralysis in only a minority of patients. J Med Virol 70:99–108, Kaufmann SH, Hengartner MO (2001) Programmed cell death: alive and well in the new millennium. Nearly 50 years later, when two effective poliovirus vaccines were developed, the impetus to study poliovirus pathogenesis waned. A four-fold rise in antibody titer in paired sera confirms the diagnosis. Biophys. Samples should be collected as early in the course of the disease as possible (ideally within 14 days after onset). Trends Cell Biol 10:369–377, Desprès P, Frenkiel MP, Ceccaldi PE, Duarte dos Santos C, Deubel V (1998) Apoptosis in the mouse central nervous system in response to infection with mouse-neurovirulent dengue viruses. The identification of the cell receptor for poliovirus, CD155, and its use in the development of transgenic mice susceptible to poliovirus revived interest in understanding how the virus causes disease. 247-257, 15 December, 2011 ... Pathogenesis of poliomyelitis and post-polio syndrome Knowledge of how the poliovirus infects the body can be helpful in understanding the possible causes of post-polio syndrome. In 1988, The global polio eradication initiative (GPEI) launched a program in which global expansion of the PV vaccine resulted in reduction of PPM from an annual level of at least 350,000 cases to only 22 cases caused by wild poliovirus (WPV) in 2017. Poliovirus (PV) is the causal agent of paralytic poliomyelitis, a disease that involves the destruction of motor neurons associated with PV replication. P ( 1998 ) viral ribonucleoprotein complex formation and nucleolar-cytoplasmic relocalization of in! 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